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Brevetoxin-3
$1,500
Only 1000 item(s) left in stock.
Products Details
Product Description
– Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain)[1]. Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation[2].
Web ID
– HY-12545
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C50H72O14
References
– [1]Jeglitsch G,et al. Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons.J Pharmacol Exp Ther. 1998 Feb;284(2):516-25.|[2]Zaias J,et al. Repeated exposure to aerosolized brevetoxin-3 induces prolonged airway hyperresponsiveness and lung inflammation in sheep.Inhal Toxicol. 2011 Mar;23(4):205-11.|[3]Benson JM, et al. Placental transport of brevetoxin-3 in CD-1 mice.Toxicon. 2006 Dec 15;48(8):1018-26. Epub 2006 Aug 18.
CAS Number
– 85079-48-7
Molecular Weight
– 897.10
Compound Purity
– 95.0
SMILES
– C[C@@]12[C@](C[C@@]3([H])[C@@](C)(CC[C@@]4([H])[C@]([C@@H](C[C@@]5([H])[C@](C[C@@]6(C)[C@](C[C@@](O7)([H])[C@](C(C)=CC7=O)([H])O6)([H])O5)([H])O4)C)([H])O3)O2)([H])O[C@]8(C)[C@@](O[C@]9([H])[C@@](O[C@]%10([H])[C@@](O[C@]%11(C)[C@@](O[C@H](CC(CO)=C)C[C@@H]%11O)([H])C%10)([H])C9)([H])/C=CC8)([H])C1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Sodium Channel
Pathway
– Membrane Transporter/Ion Channel
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
