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BRD6989
$88 – $825
Products Details
Product Description
– BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates IL-10. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes[1].
Web ID
– HY-122586
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C16H16N4
References
– [1]Johannessen L, et al. Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat Chem Biol. 2017 Oct;13(10):1102-1108
CAS Number
– 642008-81-9
Molecular Weight
– 264.33
Compound Purity
– 99.56
SMILES
– N#CC1=C(C2=CC=CN=C2)C3=C(N=C1N)CCC(C)C3
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 25 mg/mL (ultrasonic)
Target
– CDK;Interleukin Related
Isoform
– CDK19;CDK8;IL-10
Pathway
– Cell Cycle/DNA Damage;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
