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Products Details
Product Description
– BRD6688 is a selective HDAC2 inhibitor. BRD6688 increases H4K12 and H3K9 histone acetylation in primary mouse neuronal cells. BRD6688 crosses the blood brain barrier and rescues the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model[1].
Web ID
– HY-117709
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C16H18N4O
References
– [1]Wagner FF, et al. Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers. Chem Sci. 2015 Jan 1;6(1):804-815.
CAS Number
– 1404562-17-9
Molecular Weight
– 282.34
SMILES
– O=C(N1CCCC1)NC2=C(N)C=CC(C3=CC=NC=C3)=C2
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– HDAC
Isoform
– HDAC2
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
