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Products Details
Product Description
– BRD4 Inhibitor-28 (Compound 18) is an orally active BRD4 Inhibitor. BRD4 Inhibitor-28 inhibits BRD40-BD1, BRD40-BD2 with IC50s of 15, 55 nM. BRD4 Inhibitor-28 also inhibits BRD2-BD1, BRD3-BD1, BRDT-BD1 with IC50s of 19, 25, 68 nM. BRD4 Inhibitor-28 has anti-melanoma activity[1].
Web ID
– HY-149519
Shipping
– Room temperature
Molecular Formula
– C23H21N3O3
References
– [1]Horai Y, et al. Discovery of a potent, orally available tricyclic derivative as a novel BRD4 inhibitor for melanoma. Bioorg Med Chem. 2023 Aug 26;93:117461.
CAS Number
– 2468960-80-5
Molecular Weight
– 387.43
SMILES
– O=C1N2CCOC3=C2C(N1CC4=CC=CC=C4)=CC(C5=CN(C(C(C)=C5)=O)C)=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Epigenetic Reader Domain
Pathway
– Epigenetics
Product type
– Reference compound
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