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Products Details
Product Description
– BRD4 Inhibitor-28 (Compound 18) is an orally active BRD4 Inhibitor. BRD4 Inhibitor-28 inhibits BRD40-BD1, BRD40-BD2 with IC50s of 15, 55 nM. BRD4 Inhibitor-28 also inhibits BRD2-BD1, BRD3-BD1, BRDT-BD1 with IC50s of 19, 25, 68 nM. BRD4 Inhibitor-28 has anti-melanoma activity[1].
Web ID
– HY-149519
Shipping
– Room temperature
Molecular Formula
– C23H21N3O3
References
– [1]Horai Y, et al. Discovery of a potent, orally available tricyclic derivative as a novel BRD4 inhibitor for melanoma. Bioorg Med Chem. 2023 Aug 26;93:117461.
CAS Number
– 2468960-80-5
Molecular Weight
– 387.43
SMILES
– O=C1N2CCOC3=C2C(N1CC4=CC=CC=C4)=CC(C5=CN(C(C(C)=C5)=O)C)=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Epigenetic Reader Domain
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
