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Products Details
Product Description
– BRD4 Inhibitor-18 is a highly potent BRD4 inhibitor with an IC50 value of 110 nM. BRD4 Inhibitor-18 has a hydrophobic acetylcyclopentanyl side chain. BRD4 Inhibitor-18 can significantly suppress the proliferation of MV-4-11 cells with high BRD4 level. BRD4 Inhibitor-18 has apoptosis-promoting and G0/G1 cycle-arresting activity[1].
Web ID
– HY-146660
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H26ClN3O3S
References
– [1]Li Q, Li J, Cai Y, et al. Design, synthesis and biological evaluation of novel 6-phenyl-1,3a,4,10b-tetrahydro-2H-benzo[c]thiazolo[4,5-e]azepin-2-one derivatives as potential BRD4 inhibitors. Bioorg Med Chem. 2020;28(15):115601.
CAS Number
– 2451219-73-9
Molecular Weight
– 496.02
SMILES
– COC1=CC2=C(C=C1)C3=C(SC(N3C)=O)C(CC(NC4CCCC4)=O)N=C2C5=CC=C(Cl)C=C5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;c-Myc;Epigenetic Reader Domain
Isoform
– BRD4
Pathway
– Apoptosis;Epigenetics
Product type
– Reference compound
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