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Products Details
Product Description
– BRD4 Inhibitor-15 (compound 13) is a potent BRD4 inhibitor, with an IC50 of 18 nM. BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells by regulating Bcl-2/Bax proteins and activating caspase-3 signaling pathway. BRD4 Inhibitor-15 down-regulates the c-Myc level in 22RV1 cells. BRD4 Inhibitor-15 can be used for prostate cancer research[1].
Web ID
– HY-143235
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H21N3O2
References
– [1]Jiang W, et al. Design, synthesis, and evaluation of novel pyridone derivatives as potent BRD4 inhibitors for the potential treatment of prostate cancer. Bioorg Chem. 2022 Feb;119:105575.
CAS Number
– 2761366-60-1
Molecular Weight
– 359.42
SMILES
– CCOC1=CC(N(C=C1C2=CC3=C(C=NN3CC4=CC=CC=C4)C=C2)C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family;Caspase;c-Myc;Epigenetic Reader Domain
Isoform
– Bax;Bcl-2;BRD4;Caspase 3
Pathway
– Apoptosis;Epigenetics
Product type
– Reference compound
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