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Products Details
Product Description
– BRD2492 (compound 6d) is a potent, selective HDAC1 and HDAC2 inhibitor with IC50s of 13.2 nM and 77.2 nM, respecrtively. BRD2492 exhibits >100-fold selectivity for HDAC1/2 over selectivity over HDAC3 and HDAC6. BRD2492 inhibits breast cancer cell lines growth with IC50s of 1.01 μM and 11.13 μM for T-47D and MCF-7 cells, respectively[1].
Web ID
– HY-124053
Shipping
– Room temperature
Molecular Formula
– C20H18N4O2
References
– [1]Linda Schäker-Hübner, et al. Balancing Histone Deacetylase (HDAC) Inhibition and Drug-likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors. ChemMedChem. 2022 May 4;17(9):e202100755.
CAS Number
– 1821669-43-5
Molecular Weight
– 346.38
SMILES
– O=C(NC1=C(N)C=CC(C2=CC=NC=C2)=C1)C3=CC=C(NC(C)=O)C=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HDAC
Isoform
– HDAC1;HDAC2;HDAC3;HDAC6
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
