BQ-788 (sodium salt)

$180$613

Products Details

Product Description

– BQ-788 sodium salt is a potent and selective ETB receptor antagonist, inhibiting ET-1 binding to ETB receptors with an IC50 of 1.2 nM in human Girrardi heart cells[1].

Web ID

– HY-15894

Storage Temperature

– -20°C (Powder, protect from light, stored under nitrogen)

Shipping

– Blue Ice

Applications

– COVID-19-immunoregulation

Molecular Formula

– C34H50N5NaO7

Citations

– BMC Cancer. 2018 Feb 6;18(1):154.|Environ Sci Pollut Res Int. 2018 May;25(15):14713-14725.|PLoS Pathog. 2020 Oct 19;16(10):e1008947.|Cells. 2021, 10(11), 3072.|Environ Pollut. 2016 Feb;209:11-20.|Environ Pollut. 2016 Nov;218:487-496. |Neurotherapeutics. 2021 Oct 18.|Toxicol Sci. 2016 Jan;149(1):213-26.

References

– [1]Okada M, et al. BQ-788, a selective endothelin ET(B) receptor antagonist. Cardiovasc Drug Rev. 2002 Winter;20(1):53-66.|[2]Sargent CA, et al. Effect of endothelin antagonists with or without BQ 788 on ET-1 responses in pithed rats. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S216-8.|[3]Fattori V, et al. Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice. J Drug Target. 2016 Oct 5:1-27

CAS Number

– 156161-89-6

Molecular Weight

– 663.78

Compound Purity

– 98.56

SMILES

– CCCC[C@H](C(O[Na])=O)NC([C@@H](CC1=CN(C(OC)=O)C2=CC=CC=C12)NC([C@H](CC(C)(C)C)NC(N3[C@H](C)CCC[C@@H]3C)=O)=O)=O

Clinical Information

– Phase 1

Research Area

– Cardiovascular Disease; Endocrinology; Cancer

Solubility

– DMSO : ≥ 43 mg/mL|H2O : 20 mg/mL (ultrasonic)

Target

– Endothelin Receptor

Isoform

– ETB

Pathway

– GPCR/G Protein

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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