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Products Details
Product Description
– BPH-1086 (compound 10) is an IspH inhibitor, IspH domain fused with ribosomal protein S1 (RPS1) can bind to mRNA or form part of the bacterial ribosome[1][2].
Web ID
– HY-147304
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C4H8O7P2
References
– [1]Wang W, et al. Bioorganometallic mechanism of action, and inhibition, of IspH. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4522-7. |[2]Rao G, et al. IspH-RPS1 and IspH-UbiA: “Rosetta Stone” Proteins. Chem Sci. 2015 Dec 1;6(12):6813-6822. |[3]Singh KS, et al. IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance. Nature. 2021 Jan. 589(7843):597-602.|[4]Oldfield Eric, et al. Enzyme inhibiting compounds and methods: United States, US8609638 B2. 2013-12-17.|[5]Oldfield Eric, et al. Preparation of alkynyl diphosphates as Enzyme inhibiting compounds and methods: World Intellectual Property Organization, WO2011044505 A2. 2011-04-14.
CAS Number
– 1226901-43-4
Molecular Weight
– 230.05
SMILES
– O=P(O)(OP(O)(O)=O)OCC#CC
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– Bacterial
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
