Download Files:
Products Details
Product Description
– Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity[1][2][3].
Web ID
– HY-124896
Shipping
– Room temperature
Molecular Formula
– C25H28O5
References
– [1]Lai-Bin Zhang, et al. Isoprenylated Flavonoids with PTP1B Inhibition from Macaranga denticulate. Nat Prod Bioprospect. 2016 Feb;6(1):25-30.|[2]Hyun-Kyu An, et al. Mimulone-induced autophagy through p53-mediated AMPK/mTOR pathway increases caspase-mediated apoptotic cell death in A549 human lung cancer cells. PLoS One. 2014 Dec 9;9(12):e114607.|[3]Zora Vochyánová, et al. Diplacone and mimulone ameliorate dextran sulfate sodium-induced colitis in rats. Fitoterapia. 2015 Mar;101:201-7.
CAS Number
– 97126-57-3
Molecular Weight
– 408.49
SMILES
– O=C1C[C@H](OC2=C1C(O)=C(C(O)=C2)C/C=C(CC/C=C(C)C)C)C3=CC=C(C=C3)O
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Autophagy;Phosphatase
Pathway
– Apoptosis;Autophagy;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
