Download Files:
Products Details
Product Description
– BMS-986318 is a potent nonbile acid FXR agonist with EC50s of 53 and 350 nM in the FXR Gal4 and SRC-1 recruitment assays, respectively. BMS-986318 has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.BMS-986318 can be used for the research of nonalcoholic steatohepatitis[1].
Web ID
– HY-139562
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C30H23Cl2F3N4O3
References
– [1]Joseph Carpenter, et al. Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis. ACS Med Chem Lett. 2021 Aug 5;12(9):1413-1420.
CAS Number
– 2314378-09-9
Molecular Weight
– 615.43
SMILES
– O=C(C1=CC(C(F)(F)F)=C2C=C(N3CCC4(CC3)C=C(C4)C5=C(C6CC6)ON=C5C7=C(Cl)C=NC=C7Cl)C=CC2=N1)O
Clinical Information
– Phase 1
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– FXR
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
