Download Files:
Products Details
Product Description
– BMS-986143 is an orally active, reversible BTK inhibitor with an IC50 of 0.26 nM. BMS-986143 also inhibits TEC, BLK, BMX, TXK FGR, YES1, ITK with IC50s of 3 nM, 5 nM, 7 nM, 10 nM, 15 nM,19 nM, 21 nM, respectively. BMS-986143 can be used for the research of autoimmune diseases[1].
Web ID
– HY-145373
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C31H24Cl2N4O4
References
– [1]Anurag S Srivastava, et al. Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK. ACS Med Chem Lett. 2020 Sep 16;11(11):2195-2203.
CAS Number
– 1643372-83-1
Molecular Weight
– 587.45
SMILES
– CC1=C(C=CC=[C@@]1[C@@]2=C(C=C(C3=C2C4=C(N3)C=C(C=C4)C(C)(O)C)C(N)=O)Cl)N5C(C=C6C(Cl)=CC=CN6C5=O)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Btk
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
