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Products Details
Product Description
– BMS-986118 is a potent, orally active, and selective GPR40 agonist with an EC50 of 0.07 µM. BMS-986118 has dual insulinotropic and GLP-1 secretory effects, resulting in robust plasma glucose lowering effects in acute animal models[1].
Web ID
– HY-12413A
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C25H28ClF3N4O4
References
– [1]Shi J, et al. Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists. J Med Chem. 2018;61(3):681-694.
CAS Number
– 1610562-74-7
Molecular Weight
– 540.96
SMILES
– COC1=CC(N2CC[C@H]([C@@H](C2)C)OC3=CC=C(C=C3)N4[C@H]([C@@H](C(C(F)(F)F)=N4)C)CC(O)=O)=C(C=N1)Cl
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Free Fatty Acid Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
