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Products Details
Product Description
– BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor[1].
Web ID
– HY-19263
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C20H17N3O4S
References
– [1]Murugesan N, et al. Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2′-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1′-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. J Med Chem. 2003;46(1):125-137.
CAS Number
– 176960-47-7
Molecular Weight
– 395.43
SMILES
– O=S(C1=CC=CC=C1C2=CC=C(C3=NC=CO3)C=C2)(NC4=C(C)C(C)=NO4)=O
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Endothelin Receptor
Isoform
– ETA;ETB
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
