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Products Details
Product Description
– BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor[1].
Web ID
– HY-19263
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C20H17N3O4S
References
– [1]Murugesan N, et al. Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2′-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1′-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. J Med Chem. 2003;46(1):125-137.
CAS Number
– 176960-47-7
Molecular Weight
– 395.43
SMILES
– O=S(C1=CC=CC=C1C2=CC=C(C3=NC=CO3)C=C2)(NC4=C(C)C(C)=NO4)=O
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Endothelin Receptor
Isoform
– ETA;ETB
Pathway
– GPCR/G Protein
Product type
– Reference compound
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