Products Details

Product Description

– Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity[1].

Web ID

– HY-111397

Shipping

– Room temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C43H36Cl2N8O5

References

– [1]J M Woynarowski, et al. AT-rich islands in genomic DNA as a novel target for AT-specific DNA-reactive antitumor drugs. J Biol Chem. 2001 Nov 2;276(44):40555-66. |[2]J M Woynarowski, et al. Effects of bizelesin (U-77,779), a bifunctional alkylating minor groove binder, on replication of genomic and simian virus 40 DNA in BSC-1 cells. Biochim Biophys Acta. 1997 Jul 17;1353(1):50-60. 

CAS Number

– 129655-21-6

Molecular Weight

– 815.70

SMILES

– O=C(NC1=CC2=C(NC(C(N3C4=CC(O)=C5NC=C(C)C5=C4[C@H](CCl)C3)=O)=C2)C=C1)NC6=CC7=C(NC(C(N8C9=CC(O)=C%10NC=C(C)C%10=C9[C@H](CCl)C8)=O)=C7)C=C6

Clinical Information

– Phase 1

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– DNA Alkylator/Crosslinker

Pathway

– Cell Cycle/DNA Damage

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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