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Bisantrene
$45 – $264
Products Details
Product Description
– Bisantrene is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene targets eukaryotic type II topoisomerases. Bisantrene is a substrate of MDR1[1][2][3][4].
Web ID
– HY-100875
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H22N8
References
– [1]Sissi C, et al. DNA-binding preferences of Bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase II poisoning. Mol Pharmacol. 1998 Dec;54(6):1036-45.|[2]Yap HY, et al. Bisantrene, an active new drug in the treatment of metastatic breast cancer. Cancer Res. 1983 Mar;43(3):1402-4.|[3]Wang BS, et al. Activation of tumor-cytostatic macrophages with the antitumor agent 9,10-anthracenedicarboxaldehyde bis[(4,5-dihydro-1H-imidazole-2-yl)hydrazone] dihydrochloride (bisantrene). Cancer Res. 1984 Jun;44(6):2363-7. |[4]Aksentijevich I, et al. Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity. Clin Cancer Res. 1996 Jun;2(6):973-80.
CAS Number
– 78186-34-2
Molecular Weight
– 398.46
Compound Purity
– 98.08
SMILES
– C12=CC=CC=C1C(/C=N/NC3=NCCN3)=C4C(C=CC=C4)=C2/C=N/NC5=NCCN5
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : 1 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : 0.1 mg/mL (ultrasonic;warming;heat to 50°C)
Target
– Topoisomerase
Isoform
– Topo II
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
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