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bio-THZ1
$700 – $2,500
Products Details
Product Description
– bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM[1].
Web ID
– HY-128867
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C52H65ClN12O8S
References
– [1]Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20.
CAS Number
– 1604811-14-4
Molecular Weight
– 1053.67
Compound Purity
– 98.06
SMILES
– O=C(NCCOCCOCCOCCNC(NCCCN(C)C/C=C/C(NC1=CC=C(C(NC2=CC=CC(NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)=C2)=O)C=C1)=O)=O)CCCC[C@@H]6SC[C@]([C@]6([H])N7)([H])NC7=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 120 mg/mL (ultrasonic)
Target
– CDK
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
