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BG45
$72 – $576
Products Details
Product Description
– BG45 is a potent HDAC3 inhibitor with IC50 values of 0.289, 2, 2.2 and ﹥20 μM for HDAC3, HDAC1, HDAC2 and HDAC6, respectively. BG45 selectively targets multiple myeloma (MM) cells and induces caspase-dependent apoptosis[1][2].
Web ID
– HY-18712
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C11H10N4O
References
– [1]Minami J, et, al. Histone deacetylase 3 as a novel therapeutic target in multiple myeloma. Leukemia. 2014 Mar;28(3):680-9.|[2]Iaconelli J, et, al. HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cells. ACS Chem Biol. 2015 Mar 20;10(3):883-90.
CAS Number
– 926259-99-6
Molecular Weight
– 214.22
Compound Purity
– 99.96
SMILES
– O=C(C1=NC=CN=C1)NC2=CC=CC=C2N
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 48 mg/mL
Target
– Apoptosis;Caspase;HDAC
Isoform
– HDAC1;HDAC2;HDAC3;HDAC6
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
