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Betulinic acid
$60 – $210
Products Details
Product Description
– Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties[1][2][3][4].
Web ID
– HY-10529
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C30H48O3
References
– [1]Kasperczyk H, et al. Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy. Oncogene. 2005 Oct 20;24(46):6945-56.|[2]Chowdhury AR, et al. Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives. Med Sci Monit. 2002 Jul;8(7):BR254-65.|[3]Gao Y, et al. Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. 2018 Jan-Feb;42(1):49-54.|[4]Kalra J, et al. Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain in mice. Naunyn Schmiedebergs Arch Pharmacol. 2017 Dec 26.|[5]Hashimoto F, et al. Anti-AIDS agents–XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives. Bioorg Med Chem. 1997 Dec;5(12):2133-43.
CAS Number
– 472-15-1
Molecular Weight
– 456.70
Compound Purity
– 98.58
SMILES
– [H][C@@]12CC[C@@]3(C)[C@]4(C)CC[C@]5(C(O)=O)[C@@]([C@H](C(C)=C)CC5)([H])[C@@](CC[C@@]([H])3[C@@]1(C)CC[C@H](O)C2(C)C)4[H]
Clinical Information
– Phase 2
Research Area
– Cancer; Infection; Inflammation/Immunology
Solubility
– DMSO : 35.71 mg/mL (ultrasonic)
Target
– Apoptosis;Autophagy;Endogenous Metabolite;HIV;Mitophagy;NF-κB;Parasite;Topoisomerase
Isoform
– HIV-1;NF-κB;Topo I
Pathway
– Anti-infection;Apoptosis;Autophagy;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;NF-κB
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
