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Products Details
Product Description
– BET-IN-8 (Compound 27) is a potent inhibitor of BET with a Ki and Kd of 0.83 and 0.571 μM, respectively. BET-IN-8 ameliorates LPS-induced sepsis in vivo. BET-IN-8 has the potential for the research of sepsis[1].
Web ID
– HY-146292
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H21N3O4S
References
– [1]Chen X, et al. Discovery of 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis. Eur J Med Chem. 2022 May 8;238:114423
CAS Number
– 2769893-19-6
Molecular Weight
– 423.48
SMILES
– COC1=CC(C2=C(C(NC(SCC3=CC=CC=C3C)=N2)=O)C#N)=CC(OC)=C1OC
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Epigenetic Reader Domain
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
