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Products Details
Product Description
– BET-IN-19 (Compound 146) is a BET inhibitor. BET-IN-19 inhibits hlL-6 mRNA transcription (IC50 ≤ 0.3 uM), and c-myc activity in human AML MV4-11 cell (IC50 ≤ 0.3 uM)。BET-IN-19 inhibits tetra-acetylated histone H4 binding to BRD4 bromodomain 1 (IC50 ≤ 0.3 uM)[1].
Web ID
– HY-125236
Shipping
– Room temperature
Molecular Formula
– C19H19N5O
References
– [1]Bryan Cordell DUFFY, et al. Novel bicyclic bromodomain inhibitors. Patent. WO2015002754 A2.
CAS Number
– 1643947-30-1
Molecular Weight
– 333.39
SMILES
– CNC1=NC(N=CC(C2=C(C)ON=C2C)=C3)=C3N1CC4=CC=CC=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Epigenetic Reader Domain
Pathway
– Epigenetics
Product type
– Reference compound
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