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Products Details
Product Description
– BET-IN-13 is a potent BET inhibitor with an IC50 value of 1.6 nM. BET-IN-13 reduces LPS-induced TNF-α, IL-1β, IL-6, and NOS2 mRNA expression levels. BET-IN-13 shows anti-inflammatory activity. BET-IN-13 has the potential for the research of acute liver injury[1].
Web ID
– HY-152213
Shipping
– Room temperature
Molecular Formula
– C28H23N3O4S
References
– [1]Chen C, et al. Cyclization strategy leads to highly potent Bromodomain and extra-terminal (BET) Bromodomain inhibitors for the treatment of acute liver injury. Eur J Med Chem. 2022 Dec 16;247:115023.
CAS Number
– 2506823-08-9
Molecular Weight
– 497.56
SMILES
– CC1=C2C(NC=C3CN(C4=C(C(N32)=C1)C=C(C=C4)CS(C)(=O)=O)C(C5=CC=C6C=CC=CC6=C5)=O)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Epigenetic Reader Domain
Isoform
– BRD2;BRD3;BRD4;BRDT
Pathway
– Epigenetics
Product type
– Reference compound
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