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Product Description
– Benztropine-d3 (mesylate) is the deuterium labeled Benztropine mesylate[1]. Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson’s disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects[2][3].
Web ID
– HY-B0520AS1
Shipping
– Room temperature
Molecular Formula
– C22H26D3NO4S
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Santosh S Kulkarni, et al. Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H(1) receptors. Bioorg Med Chem. 2006 Jun 1;14(11):3625-34.|[3]Jihong Cui, et al. New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. Oncotarget. 2017 Jan 38(1):1007-1022.
CAS Number
– 202529-16-6
Molecular Weight
– 406.55
SMILES
– CS(=O)(O)=O.[2H]C([2H])([2H])N([C@@H](CC1)C2)[C@H]1C[C@@H]2OC(C3=CC=CC=C3)C4=CC=CC=C4
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Dopamine Receptor;Histamine Receptor;mAChR
Pathway
– GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Product type
– Isotope-Labeled Compounds
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