Bemesetron

$75$120

Products Details

Product Description

– Bemesetron (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM[1]. Neuroprotective effect[2].

Web ID

– HY-B1541

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Neuroscience-Neuromodulation

Molecular Formula

– C15H17Cl2NO2

References

– [1]Peters JA, et al. An electrophysiological investigation of the properties of 5-HT<sub>3</sub> receptors of rabbit nodose ganglion neurones in culture. Br J Pharmacol. 1993 Oct;110(2):665-76.|[2]Lee HJ, et al. Blockade of 5-HT(3) receptor with MDL7222 and Y25130 reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells. Life Sci. 2005 Dec 5;78(3):294-300.|[3]Silva SR, et al. Effects of 5-HT<sub>3</sub> receptor antagonists on neuroleptic-induced catalepsy in mice. Neuropharmacology. 1995 Jan;34(1):97-9.

CAS Number

– 40796-97-2

Molecular Weight

– 314.21

Compound Purity

– 99.0

SMILES

– O=C(O[C@@H]1C[C@@H](N2C)CC[C@@H]2C1)C3=CC(Cl)=CC(Cl)=C3

Clinical Information

– No Development Reported

Research Area

– Neurological Disease

Solubility

– DMSO : 2 mg/mL (ultrasonic)

Target

– 5-HT Receptor

Isoform

– 5-HT3 Receptor

Pathway

– GPCR/G Protein;Neuronal Signaling

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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