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Beclometasone dipropionate-d10
$570
Only 1000 item(s) left in stock.
Products Details
Product Description
– Beclometasone dipropionate-d10 is the deuterium labeled Beclometasone dipropionate. Betamethasone dipropionate, the proagent of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release[1][2].
Web ID
– HY-13571AS1
Shipping
– Room temperature
Molecular Formula
– C28H27D10ClO7
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Paola Lovato, et al. Calcipotriol and betamethasone dipropionate exert additive inhibitory effects on the cytokine expression of inflammatory dendritic cell-Th17 cell axis in psoriasis. J Dermatol Sci. 2016 Mar;81(3):153-64.|[3]M Corbel, et al. Comparative effects of betamethasone, cyclosporin and nedocromil sodium in acute pulmonary inflammation and metalloproteinase activities in bronchoalveolar lavage fluid from mice exposed to lipopolysaccharide. Pulm Pharmacol Ther. 1999;12(3):165-71.
Molecular Weight
– 531.10
SMILES
– O=C(C([2H])([2H])C([2H])([2H])[2H])OCC([C@@]1([C@@]2([C@@]([C@@]3([H])[C@]([C@H](C2)O)([C@@]4(C(CC3)=CC(C=C4)=O)C)Cl)([H])C[C@@H]1C)C)OC(C([2H])([2H])C([2H])([2H])[2H])=O)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Endocrinology
Solubility
– 10 mM in DMSO
Target
– Glucocorticoid Receptor;Isotope-Labeled Compounds
Pathway
– Immunology/Inflammation;Others;Vitamin D Related/Nuclear Receptor
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
