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Products Details
Product Description
– Beauverolide Ja, a cyclotetradepsipeptide, is a potent calmodulin (CaM) inhibitor with a Kd of 0.078 μM and a Ki of 0.39 μM for Ca2+-CaM. Beauverolide Ja is a secondary metabolite of Isaria fumosorosea[1].
Web ID
– HY-142087
Shipping
– Room temperature
Molecular Formula
– C35H46N4O5
References
– [1]Abraham Madariaga-Mazón, et al. Potent anti-calmodulin activity of cyclotetradepsipeptides isolated from Isaria fumosorosea using a newly designed biosensor. Nat Prod Commun. 2015 Jan;10(1):113-6.|[2]Qunfang Weng, et al. Secondary Metabolites and the Risks of <i>Isaria fumosorosea</i> and <i>Isaria farinose</i>. Molecules. 2019 Feb 13;24(4):664.
CAS Number
– 76265-41-3
Molecular Weight
– 602.76
SMILES
– O=C(N[C@H](C(N[C@](C(OC(CC(N1)=O)C(C)CCCC)=O)([H])[C@@H](C)CC)=O)CC2=CC=CC=C2)[C@@H]1CC3=CNC4=CC=CC=C34
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Calmodulin;Endogenous Metabolite
Isoform
– Microbial Metabolite
Pathway
– Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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