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Bazedoxifene
$100 – $700
Products Details
Product Description
– Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[1][2].
Web ID
– HY-A0031
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C30H34N2O3
Citations
– Breast Cancer Res Treat. 2020 Jan;179(1):67-77.|Eur J Pharmacol. 2023 Mar 24;947:175681.|Free Radic Biol Med. 2023 Aug, 139, 108897.|Glia. 2022 Sep 12.|Gynecol Oncol. 2019 Jul;154(1):199-206.|J Cell Biochem. 2023 Aug 11.|Research Square Preprint. 2020 Nov 4;rs.3.rs-100914.|Research Square Preprint. 2022 Jul.|J Med Chem. 2020 Oct 8;63(19):11085-11099.|mSphere. 2020 Apr 8;5(2):e00124-20.
References
– [1]Barry S Komm, et al. Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology. 2005 Sep;146(9):3999-4008.|[2]Xiaojuan Wu, et al. Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy. Mol Cancer Ther. 2016 Nov; 15(11): 2609–2619.
CAS Number
– 198481-32-2
Molecular Weight
– 470.60
Compound Purity
– 99.35
SMILES
– CC1=C(C2=CC=C(O)C=C2)N(CC3=CC=C(OCCN4CCCCCC4)C=C3)C5=CC=C(O)C=C51
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Estrogen Receptor/ERR
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
