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Products Details
Product Description
– Bay 65-1942 free base is an ATP-competitive and selective IKKβ inhibitor.
Web ID
– HY-50949
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H25N3O4
Citations
– Oncogene. 2016 Aug 4;35(31):4036-47.|Cell Mol Immunol. 2023 Mar 2;1-14.|Int Immunopharmacol. 2020 Nov;88:107020.
References
– [1]Moss NC, et al. IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2248-53.|[2]Cooper MJ, et al. Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia. PLoS One. 2013 Jun 24;8(6):e66755.
CAS Number
– 600734-02-9
Molecular Weight
– 395.45
SMILES
– O=C1OCC2=C([C@H]3CNCCC3)C=C(C4=C(O)C=CC=C4OCC5CC5)N=C2N1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– IKK
Isoform
– IKK-β
Pathway
– NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
