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Product Description
– Barnidipine-d5 (hydrochloride) is the deuterium labeled Barnidipine hydrochloride. Barnidipine hydrochloride (Mepirodipine hydrochloride) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors[1].Barnidipine hydrochloride (Mepirodipine hydrochloride) is an antihypertensive agent and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action[2].
Web ID
– HY-107322S
Shipping
– Room temperature
Molecular Formula
– C27H25D5ClN3O6
References
– [1]van Zwieten PA, et al. Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist. Blood Press Suppl. 1998;1:5-8.|[2]Malhotra HS, et al. Barnidipine. Drugs. 2001;61(7):989-96; discussion 997-8.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Molecular Weight
– 533.03
SMILES
– CC1=C([C@@H](C2=CC([N+]([O-])=O)=CC=C2)C(C(OC)=O)=C(N1)C)C(O[C@@H]3CN(CC3)CC4=C(C([2H])=C(C([2H])=C4[2H])[2H])[2H])=O.Cl
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Calcium Channel;Isotope-Labeled Compounds
Isoform
– L-type calcium channel
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling;Others
Product type
– Isotope-Labeled Compounds
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