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Bardoxolone
$88 – $330
Products Details
Product Description
– Bardoxolone is a novel nuclear regulator factor (Nrf-2) activator.
Web ID
– HY-14909
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C31H41NO4
References
– [1]McCullough PA, et al. Cardiac and renal function in patients with type 2 diabetes who have chronic kidney disease: potential effectsof bardoxolone methyl. Drug Des Devel Ther. 2012;6:141-9.|[2]Reisman SA, et al.
Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney.
J Am Soc Nephrol. 2012 Oct;23(10):1663-73.|[3]Dinh CH, et al. Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice. ScientificWorldJournal. 2015;2015:549352.|[4]Hong DS, et al.
A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas.
Clin Cancer Res. 2012 Jun 15;18(12):3396-406.
CAS Number
– 218600-44-3
Molecular Weight
– 491.66
Compound Purity
– 99.14
SMILES
– CC1(C)CC[C@@]2(C(O)=O)[C@@]([C@](C(C=C3[C@@]4(C)CC[C@]5([H])[C@]3(C)C=C(C#N)C(C5(C)C)=O)=O)([H])[C@@]4(C)CC2)([H])C1
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Keap1-Nrf2
Pathway
– NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
