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Products Details
Product Description
– Balsalazide-d4 is deuterium labeled Balsalazide. Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
Web ID
– HY-B0667S1
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C17H11D4N3O6
References
– [1]Do EJ, et al. Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3. J Gastroenterol Hepatol. 2016 Aug;31(8):1453-61.|[2]Kruis W, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut, 2001. 49(6): p. 783-789.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
CAS Number
– 2714315-25-8
Molecular Weight
– 361.34
SMILES
– O=C(O)C1=CC(/N=N/C2=C([2H])C([2H])=C(C(NCCC(O)=O)=O)C([2H])=C2[2H])=CC=C1O
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Interleukin Related;Isotope-Labeled Compounds;STAT
Isoform
– IL-6
Pathway
– Immunology/Inflammation;JAK/STAT Signaling;Others;Stem Cell/Wnt
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
