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Products Details
Product Description
– BACE1-IN-6 is a BACE1 inhibitor with an IC50 value of 1.5 nM.
Web ID
– HY-145345
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C25H23F2N5O2S
References
– [1]Frohn M, et al. The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement. Bioorg Med Chem Lett. 2020 Jul 15;30(14):127240.
CAS Number
– 2079945-75-6
Molecular Weight
– 495.54
SMILES
– O=C(N1CCOCC1)[C@@]23[C@@]([C@](N=C(S3)N)(C4=CC(/C=C(C5=CC=C(C=N5)C#N)F)=CC=C4F)C)([H])C2
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Beta-secretase
Isoform
– BACE1
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
