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Products Details
Product Description
– BACE1-IN-11 is a BACE1 inhibitor. BACE1-IN-11 has the BACE1 inhibitory activity with an IC50 value of 72 μM. BACE1-IN-11 can be used for the research of Alzheimer’s disease (AD) [1].
Web ID
– HY-151348
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C30H51N5O8S
References
– [1]Takuya Otani, et al. Macrocyclic BACE1 inhibitors with hydrophobic cross-linked structures: Optimization of ring size and ring structure. Bioorg Med Chem. 2021 Dec 15;52:116517.
CAS Number
– 1803952-77-3
Molecular Weight
– 641.82
SMILES
– CCC[C@@H](C(O)=O)NC[C@H]([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)NC([C@H](CCC(O)=O)N)=O)=O)CC1=CC=CS1)=O)CC(C)C)O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Beta-secretase
Isoform
– BACE1
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
