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Products Details
Product Description
– BACE1/2-IN-1 (compound 34) is a potent BACE1 and BACE2 inhibitor, with an IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 shows a combination of lower Pgp efflux ratio and improved passive permeability. BACE1/2-IN-1 displays reduced liver microsomal metabolic stability[1].
Web ID
– HY-147758
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C21H31N5OS
References
– [1]Winneroski LL, et al. Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints. Bioorg Med Chem. 2020 Jan 1;28(1):115194.
CAS Number
– 2671036-34-1
Molecular Weight
– 401.57
SMILES
– NC1=N[C@](CN(C2=NC=CC=N2)C3)([C@]4([H])C[C@]4(C(C)(C)OC[C@@H]5C[C@H]5C)[H])[C@@H]3CS1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Amyloid-β;Beta-secretase
Isoform
– BACE1;BACE2
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
