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Products Details
Product Description
– BACE-1 inhibitor 2 is a potent and CNS permeable BACE-1 inhibitor with an IC50 of 1.5 nM in BACE-1 enzymatic assay[1].
Web ID
– HY-131068
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C21H21F4N5O3
References
– [1]Aldo Peschiulli , et al. 3,3-Difluoro-3,4,5,6-tetrahydropyridin-2-amines: Potent and Permeable BACE-1 Inhibitors. Bioorg Med Chem Lett. 2020 Apr 15;30(8):126999.
CAS Number
– 2563970-92-1
Molecular Weight
– 467.42
SMILES
– [H][C@]12CC(F)(C(N)=N[C@@]1(C3=C(C=CC(NC(C4=NC=C(N=C4)OCF)=O)=C3)F)CO[C@@H](C)C2)F
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Beta-secretase
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
