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Products Details
Product Description
– B-Raf IN 9 (compound 8b) is a potent B-Raf inhibitor, with an IC50 of 24.79 nM. B-Raf IN 9 induces apoptosis and shows cell cycle arrest at G2/M phase. B-Raf IN 9 exhibits potent antitumor activity against human prostate cancer PC-3 cell line, with an IC50 of 7.83 µM[1].
Web ID
– HY-147854
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C23H20N4OS
References
– [1]Thabit MG, et al. Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity. Bioorg Chem. 2020 Oct;103:104148.
CAS Number
– 2477725-18-9
Molecular Weight
– 400.50
SMILES
– S=C(NC1=CC=CC=C1)NC2=CC=C(C(CC3)=NN(C4=CC=CC=C4)C3=O)C=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Raf
Isoform
– BRaf
Pathway
– Apoptosis;MAPK/ERK Pathway
Product type
– Reference compound
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