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AZT triphosphate (tetraammonium)
$250 – $8,200
Products Details
Product Description
– AZT triphosphate (3′-Azido-3′-deoxythymidine-5′-triphosphate) tetraammonium is an active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate tetraammonium exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate tetraammonium also inhibits the DNA polymerase of HBV. AZT triphosphate tetraammonium activates the mitochondria-mediated apoptosis pathway[1][2][3].
Web ID
– HY-116364B
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture and light)
Shipping
– Blue Ice
Applications
– COVID-19-anti-virus
Molecular Formula
– C10H28N9O13P3
References
– [1]Ryosuke Nomura, et al. Azidothymidine-triphosphate Impairs Mitochondrial Dynamics by Disrupting the Quality Control System. Redox Biol. 2017 Oct;13:407-417.|[2]Takeya Sato, et al. Engineered Human tmpk/AZT as a Novel Enzyme/Prodrug Axis for Suicide Gene Therapy. Mol Ther. 2007 May;15(5):962-70.|[3]K Y Hostetler, et al. Enhanced Oral Absorption and Antiviral Activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and Related Compounds in Hepatitis B Virus Infection, in Vitro. Biochem Pharmacol. 1997 Jun 15;53(12):1815-22.
CAS Number
– 106060-92-8
Molecular Weight
– 575.30
Compound Purity
– 99.45
SMILES
– O=C1NC(N([C@@H](C[C@@H]2N=[N+]=[N-])O[C@@H]2COP(OP(O)(OP(O)(O)=O)=O)(O)=O)C=C1C)=O.N.N.N.N
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– DMSO : 100 mg/mL (ultrasonic;warming;heat to 70°C)
Target
– Apoptosis;DNA/RNA Synthesis;HBV;HIV;Reactive Oxygen Species
Pathway
– Anti-infection;Apoptosis;Cell Cycle/DNA Damage;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
