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Azoramide
$45 – $270
Products Details
Product Description
– Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR). Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating unfolded protein response, and enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity[1][2].
Web ID
– HY-18705
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C15H17ClN2OS
References
– [1]Fu S, et, al. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Sci Transl Med. 2015 Jun 17;7(292):292ra98.|[2]Ke M, et, al. Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling. Cell Death Dis. 2020 Feb 18;11(2):130.
CAS Number
– 932986-18-0
Molecular Weight
– 308.83
Compound Purity
– 98.63
SMILES
– CCCC(NCCC1=CSC(C2=CC=C(Cl)C=C2)=N1)=O
Clinical Information
– No Development Reported
Research Area
– Endocrinology
Solubility
– DMSO : ≥ 30 mg/mL|Ethanol : 2 mg/mL (ultrasonic)
Target
– Apoptosis;Bcl-2 Family;Caspase;Mitochondrial Metabolism;Reactive Oxygen Species
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
