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Azepexole (dihydrochloride)

Products Details

Product Description

– Azepexole (B-HT 933) dihydrochloride is a potent and selective alpha 2-adrenoceptor agonist with pKis of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively[1]. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions (IC50= 78.72 nM)[2].

Web ID

– HY-103212

Shipping

– Room temperature

Applications

– Metabolism-protein/nucleotide metabolism

Molecular Formula

– C9H17Cl2N3O

References

– [1]Altamirano-Espinoza AH, et al. Specific role of α2A – and α2B -, but not α2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats. Basic Clin Pharmacol Toxicol. 2015;117(1):31-38.

CAS Number

– 36067-72-8

Molecular Weight

– 254.16

SMILES

– NC(O1)=NC2=C1CCN(CC)CC2.[H]Cl.[H]Cl

Clinical Information

– No Development Reported

Research Area

– Endocrinology; Cardiovascular Disease

Solubility

– 10 mM in DMSO

Target

– Adrenergic Receptor

Isoform

– α adrenergic receptor

Pathway

– GPCR/G Protein;Neuronal Signaling

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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