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Products Details
Product Description
– Azepexole (B-HT 933) dihydrochloride is a potent and selective alpha 2-adrenoceptor agonist with pKis of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively[1]. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions (IC50= 78.72 nM)[2].
Web ID
– HY-103212
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C9H17Cl2N3O
References
– [1]Altamirano-Espinoza AH, et al. Specific role of α2A – and α2B -, but not α2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats. Basic Clin Pharmacol Toxicol. 2015;117(1):31-38.
CAS Number
– 36067-72-8
Molecular Weight
– 254.16
SMILES
– NC(O1)=NC2=C1CCN(CC)CC2.[H]Cl.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Endocrinology; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Adrenergic Receptor
Isoform
– α adrenergic receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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