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AzddMeC
$210 – $1,800
Products Details
Product Description
– AzddMeC (CS-92) is an antiviral nucleoside analogue and a potent potent, selective and orally active HIV-1 reverse transcriptase and HIV-1 replication inhibitor. In HIV-1-infected human PBM cells and HIV-1-infected human macrophages, the EC50 values of AzddMeC are 9 nM and 6 nM, respectively[1][2]. AzddMeC is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
Web ID
– HY-105268
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C10H14N6O3
References
– [1]R F Schinazi, et al. Antiretroviral Activity, Biochemistry, and Pharmacokinetics of 3′-azido-2′,3′-dideoxy-5-methylcytidine. Ann N Y Acad Sci. 1990;616:385-97.|[2]Boudinot FD, et al. Pharmacokinetics and metabolism of 3′-azido-2′,3′-dideoxy-5-methylcytidine in rhesus monkeys. Drug Metab Dispos. 1993;21(5):855‐860.
CAS Number
– 87190-79-2
Molecular Weight
– 266.26
Compound Purity
– 98.96
SMILES
– O=C1N([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C=C(C)C(N)=N1
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– DMSO : 200 mg/mL (ultrasonic)
Target
– HIV;Nucleoside Antimetabolite/Analog;Reverse Transcriptase
Isoform
– HIV-1;HIV-2
Pathway
– Anti-infection;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
