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AZD8330

SKU HY-12058-10 mg Category Tags , ,

$145$1,254

Products Details

Product Description

– AZD8330 (ARRY-424704) is a potent, uncompetitive MEK1/MEK2 inhibitor, with an IC50 of 7 nM.

Web ID

– HY-12058

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C16H17FIN3O4

References

– [1]Cohen RB, et al. A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignancies. Eur J Cancer. 2013 May;49(7):1521-9.|[2]Baranski Z, et al. MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation. Genes Cancer. 2015 Nov;6(11-12):503-12.

CAS Number

– 869357-68-6

Molecular Weight

– 461.23

Compound Purity

– 99.14

SMILES

– IC1=CC(F)=C(C=C1)NC(N2C)=C(C=C(C2=O)C)C(NOCCO)=O

Clinical Information

– Phase 1

Research Area

– Cancer

Solubility

– DMSO : ≥ 100 mg/mL

Target

– MEK

Isoform

– MEK1;MEK2

Pathway

– MAPK/ERK Pathway

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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