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Products Details
Product Description
– AZ12253801 is an ATP-competitive IGF-1R tyrosine kinase inhibitor that shows ∼10-fold selectivity over the insulin receptor. AZ12253801 inhibits IGF-1R–driven proliferation in 3T3 mouse fibroblasts (transfected with human IGF-1R) with an IC50 of 17 nmol/L. The IC50 for epidermal growth factor receptor (EGFR)–driven proliferation is 440 nmol/L. Anti-tumor activity.
Web ID
– HY-125102
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H22N8O
References
– [1]https://aacrjournals.org/cancerres/article/70/16/6412/559448/Type-1-Insulin-like-Growth-Factor-Receptor
CAS Number
– 851432-37-6
Molecular Weight
– 402.45
SMILES
– [H][C@](CCC1)(C2=CC(C3=CC=CC=N3)=NO2)N1C4=NC(C)=CC(NC5=NNC(C)=C5)=N4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– IGF-1R
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
