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AWZ1066S
$205 – $1,450
Products Details
Product Description
– AWZ1066S is a highly potent, specific and orally active anti-Wolbachia agent with EC50 value of 121 nM. AWZ1066S also is a weak CYP2C9 inhibitor and a weak CYP3A4 inducer with IC50 values of 9.7 μM and 37 uM, respectively. AWZ1066S can be used for the research of tropical diseases such as Onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis) [1].
Web ID
– HY-114415
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H19F3N6O
References
– [1]Hong WD, et al. AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1414-1419.
CAS Number
– 2239272-16-1
Molecular Weight
– 404.39
Compound Purity
– 98.65
SMILES
– C[C@@H](COCC1)N1C2=NC3=C(C=CC=N3)C(NCC4=CC=CN=C4C(F)(F)F)=N2
Clinical Information
– Phase 1
Research Area
– Infection
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– Parasite
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
