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Products Details
Product Description
– Aviculin, a lignan glycoside, is a potent anticancer agent. Aviculin reduces metabolic activity on MCF-7 cells below 50%, with an IC50 of 75.47 μM. Aviculin induces breast cancer cell apoptosis through the intrinsic apoptosis pathway. Aviculin increases expression of initiator caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP). Aviculin shows an increase in the Bax/Bcl-2 ratio[1].
Web ID
– HY-N10481
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H34O10
References
– [1]Lee D, et al. Aviculin Isolated from Lespedeza cuneata Induce Apoptosis in Breast Cancer Cells through Mitochondria-Mediated Caspase Activation Pathway. Molecules. 2020 Apr 8;25(7):1708.
CAS Number
– 156765-33-2
Molecular Weight
– 506.54
SMILES
– O[C@H]([C@@H]([C@H]([C@@H](O1)C)O)O)[C@@H]1OC[C@@H]2[C@@H](C3=CC(OC)=C(C=C3)O)C4=CC(O)=C(OC)C=C4C[C@H]2CO
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family;Caspase;PARP
Isoform
– Bax;Bcl-2;Caspase 7;Caspase 9;PARP
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
