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Products Details
Product Description
– Aviculin, a lignan glycoside, is a potent anticancer agent. Aviculin reduces metabolic activity on MCF-7 cells below 50%, with an IC50 of 75.47 μM. Aviculin induces breast cancer cell apoptosis through the intrinsic apoptosis pathway. Aviculin increases expression of initiator caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP). Aviculin shows an increase in the Bax/Bcl-2 ratio[1].
Web ID
– HY-N10481
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H34O10
References
– [1]Lee D, et al. Aviculin Isolated from Lespedeza cuneata Induce Apoptosis in Breast Cancer Cells through Mitochondria-Mediated Caspase Activation Pathway. Molecules. 2020 Apr 8;25(7):1708.
CAS Number
– 156765-33-2
Molecular Weight
– 506.54
SMILES
– O[C@H]([C@@H]([C@H]([C@@H](O1)C)O)O)[C@@H]1OC[C@@H]2[C@@H](C3=CC(OC)=C(C=C3)O)C4=CC(O)=C(OC)C=C4C[C@H]2CO
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family;Caspase;PARP
Isoform
– Bax;Bcl-2;Caspase 7;Caspase 9;PARP
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Natural Products
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