Download Files:
Products Details
Product Description
– Avibactam sodium (NXL-104) dihydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].
Web ID
– HY-14879C
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C7H14N3NaO8S
References
– [1]Ehmann DE, Jahic H, Ross PL, Gu RF, Hu J, Kern G, Walkup GK, Fisher SL.
Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor.
Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8.|[2]Castanheira M, Sader HS, Farrell DJ, Mendes RE, Jones RN.
Activity of Ceftaroline-Avibactam Tested against Gram-Negative Organism Populations, including Strains Expressing One or More β-Lactamases and Methicillin-Resistant Staphylococcus aureus Carrying Various Staphylococcal Cassette Chromosome mec Types.
Antimicrob Agents Chemother. 2012 Sep;56(9):4779-85.|[3]Livermore DM, Mushtaq S, Barker K, Hope R, Warner M, Woodford N.
Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104).
J Antimicrob Chemother. 2012 Jun;67(6):1354-8.|[4]Zhang W, et al. In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase-producing Klebsiella pneumoniae. Antimicrob Resist Infect Control. 2018 Nov 21;7:142.
Molecular Weight
– 323.26
SMILES
– O=S(ON1[C@]2([H])CC[C@@H](C(N)=O)[N@@](C2)C1=O)(O[Na])=O.O.O
Clinical Information
– Launched
Research Area
– Infection
Solubility
– 10 mM in H2O
Target
– Antibiotic;Bacterial
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
