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Products Details
Product Description
– Autophagy inducer 2 (Compound 11i) is a potent autophagy inducer. Autophagy inducer 2 exhibits apparent antiproliferative activity against the MCF-7 cell line with an IC50 value of 1.31 μM and remarkably inhibits the colony formation of the MCF-7 cells. Autophagy inducer 2 arrests the MCF-7 cells in the G2/M phase by regulating the cell-cycle-related proteins Cdk-1 and Cyclin B1. Autophagy inducer 2 has the potential for the research of breast cancer[1].
Web ID
– HY-144637
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C41H58N6O
References
– [1] Feng Y, et al. Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7. Eur J Med Chem. 2022;234:114254.
CAS Number
– 2684238-37-5
Molecular Weight
– 650.94
SMILES
– C[C@]12[C@@]([C@]3(C(C4=CC5=NC=CN=C5C(C)=C4C=C3)=CC1)C)(CC[C@@]6([C@@]2([H])C[C@@](C)(CC6)NC(N7CCN(C8CCN(CC8)C)CC7)=O)C)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Autophagy
Pathway
– Apoptosis;Autophagy
Product type
– Reference compound
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