Download Files:
Products Details
Product Description
– Aurora Kinases-IN-2 (compound 12Aj) is a potent Aurora kinases inhibitor with IC50 values of 90 and 152 nM for Aurora A and Aurora B. Aurora Kinases-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora Kinases-IN-2 can be used for cancer research[1].
Web ID
– HY-150592
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H18ClN5O3
References
– [1]Bo YX, et, al. Synthesis, biological evaluation and molecular modeling study of 2-amino-3,5-disubstituted-pyrazines as Aurora kinases inhibitors. Bioorg Med Chem. 2020 Mar 1;28(5):115351.
CAS Number
– 2241914-86-1
Molecular Weight
– 435.86
SMILES
– O=C(NC1=CC=CC(Cl)=C1)C2=CC=C(OC3=NC(C4=C(C)ON=C4C)=CN=C3N)C=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Aurora Kinase
Isoform
– Aurora A;Aurora B
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
