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Products Details
Product Description
– Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC50s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity[1].
Web ID
– HY-144307
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C16H14N6OSe2
References
– [1]Bijian K, et al. Novel Aurora A and Protein Kinase C (α, β1, β2, and θ) Multitarget Inhibitors: Impact of Selenium Atoms on the Potency and Selectivity. J Med Chem. 2022;65(4):3134-3150.
Molecular Weight
– 464.24
SMILES
– O=C1N(C2=NC(N[C@@H]3C[Se]CC3)=C4N=CNC4=N2)[Se]C5=C1C=CC=C5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Aurora Kinase;PKC
Isoform
– Aurora A;PKCα
Pathway
– Cell Cycle/DNA Damage;Epigenetics;TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
