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Products Details
Product Description
– Aurora A inhibitor 3 (Compound 5h) inhibits Aurora-A kinase with an IC50 value of 0.78 μM. Aurora A inhibitor 3 is cytotoxic, with GI50 values of 0.12 μM and 0.63 μM for MCF-7 and MDA-MB-231 cells, respectively[1].
Web ID
– HY-156378
Shipping
– Room temperature
Molecular Formula
– C22H21ClFN5
References
– [1]Yevale DB, et al. A novel class of pyrazole analogues as aurora kinase A inhibitor: design, synthesis, and anticancer evaluation. Bioorg Chem. 2023 Dec;141:106901.
Molecular Weight
– 409.89
SMILES
– CC1=NN(C2=CC=C(F)C=C2)C(N3C=CN=C3)=C1CNCC4=CC=C(Cl)C=C4C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Aurora Kinase
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
